INTRODUCTION:

Chronic myelogenous (or myeloid) leukemia (CML), also known as chronic granulocytic leukemia (CGL), is a form of leukemia characterized by the increased and unregulated growth of predominantly myeloid cells in the bone marrow and the accumulation of these cells in the blood. CML is a clonal bone marrow stem cell disorder in which proliferation of mature granulocytes (neutrophils, eosinophils, and basophils) and their precursors is the main finding. It is a type of myeloproliferative disease associated with a characteristic chromosomal translocation called the Philadelphia chromosome. Historically, it has been treated with chemotherapy, interferon and bone marrow transplantation, although targeted therapies introduced at the beginning of the 21st century have radically changed the management of CML.[1]

• Go to http://www.genome.jp/kegg/



• Go to kegg disease.
• Click on human diseases.
• Type chronic myeloid leukemia and click on search.
• Click on H00004 chronic myeloid leukemia, this will give a detail page on the disease.
• Select p53 tumor protein and click on accession number 7157.
• Select chronic myeloid leukemia hsa05220 to get pathway.
• Click on p53 signalling pathway.
• This will give signaling pathway for p53 tumour protein associated with disease chronic myeloid leukemia.
• To get structure of p53 protein go to structure link on this page.

Here structures for different domains of p53 are present. Click on one of them suppose 2QXA.

We will get the following page.

• Go down and click launch jmol to find 3d structure of this domain of protein p53.
• We will get the following result.
• The most interesting thing is that we can move 3d structure of this domain within this window by clicking the mouse and moving it.
• After moving the structure different view is obtained like the above one.
• In this way we can find the structre and pathway of our required protein associated with a disease.

REFFERENCES:

[1].http://en.wikipedia.org/wiki/Chronic_myelogenous_leukemia

Contributed by: Maleeha Jamal